Table 1.
Frequency of binucleated cells with micronucleus and Nuclear Division Index (NDI) in CBMN assay performed in three independent experiments with higher concentrations of digoxin in the CHO-K1 cell line
| Treatments (µM) | BNMN | NDI | |||||
|---|---|---|---|---|---|---|---|
| Experiments | Mean | SD | Mean | SD | |||
| I | II | III | |||||
| 0.0 | 4 | 6 | 7 | 5.7 | 1.2 | 1.56 | 0.01 |
| 20 | 9 | 13 | 14 | 12.0* | 2.2 | 1.31* | 0.02 |
| 35 | 13 | 16 | 15 | 14.7* | 1.2 | 1.38* | 0.02 |
| 50 | 12 | 14 | 15 | 13.7* | 1.2 | 1.39* | 0.03 |
| MMS | 36 | 39 | 40 | 38.0* | 1.7 | 1.31* | 0.01 |
BNMN binucleated cells with micronucleus; SD standard deviation; MMS methyl methanesulfonate (400 µM)
* Statistically different (p < 0.05) from negative control (0.0 µM)