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. 2017 Jul 12;7:5238. doi: 10.1038/s41598-017-05566-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Type-I IFN response is detected in both HSAneg and HSApos MØ. (A) Commonly enriched transcripts in HSAneg and HSApos MØ at 6 dpi are associated with type-I (IFNα and IFNβ) and type-II (IFNγ) IFN signaling pathways. (B) Transcriptional expression of type-I IFN-associated genes is commonly modulated in HSApos and HSAneg MØ. Data are presented as Log2 FC of FPKM. (C) Transcriptional expression of several members of the APOBEC family genes is affected in both HSAneg and HSApos MØ. Expression of most type-I IFN-associated transcripts is significantly up-regulated in both HSAneg and HSApos MØ (D) but a large number of these genes is also down-regulated (E) (Cut-off: FC = 1.5, p value = 0.001). A complete list displaying the distribution of DEGs is shown in the Supplementary Table S12.