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. 2017 Jul 12;7:5188. doi: 10.1038/s41598-017-05406-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FASTClear provides an efficient myocardial tissue clearing protocol. (A–C) representative images of a myocardial slice before FASTClear, after SDS buffer treatment and after FASTClear protocol. (D) During tissue clearing the architecture and proportions of the myocardium is preserved and no changes in the inter-capillary distance to capillary diameter ratio were observed. Error bar = SEM. P > 0.05 T-test. (E–G) Orthogonal view of a myocardial slice after 48 hours antibody incubation, the labelling is limited to the surface of the preparation. (H–J) Orthogonal view of a myocardial slice after 1 week of antibody incubation. The labelling is homogeneously distributed and reached the core of the preparation. At least 3 slices were used for each experiment.