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. 2017 Jul 12;7:5248. doi: 10.1038/s41598-017-05578-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spontaneous spike train and action potential characteristics obtained from simulations. (A) The in silico dopamine neuron fired spontaneously at a rate of 3.6 Hz and the CV of ISIs is equal to 0.13. The spike train was characterised by slow depolarisation preceding the spike, followed by a pronounced post-spike AHP. (B) Average action potential waveforms obtained from the model superimposed with those obtained from the SNc and VTA. The average waveforms were aligned at the point of maximum rate of rise. (Experimental waveforms adapted from ref. 55).