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. 2017 Jul 12;7:5248. doi: 10.1038/s41598-017-05578-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SK channel inhibition causes a decrease in rate of rise in membrane voltage. Phase-plane plot showed a clear reduction in rate of change in membrane voltage during a simulated SK channel inhibition (red) compared to control (black). (B) This was quantified by a significant decrease in the maximum value of rate of rise of membrane voltage, which is indicative of sodium channel unavailability. Error bars indicate mean ± S.E.M, not visible due to small errors.