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. 2017 Jul 12;7:5227. doi: 10.1038/s41598-017-05663-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The areas of flow void in the choroid capillary OCTA slab in individual DR severity grades. The non-flow areas within the CSF in the 29-μm-thick choroid capillary slab of the default setting (A) or the 10-μm-thick choriocapillaris layer (B) increase gradually according to individual DR severity grades in all 108 eyes. Areas of flow void in the 10-μm-thick choriocapillaris layer in eyes without (C) and with (D) center-involved DME.