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. 2017 Jul 12;7:5185. doi: 10.1038/s41598-017-04279-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-frequency hearing is desensitized and detuned and low-mid frequency hearing is sensitized in Cx26 cKO mice. (A) Compound action potential (CAP) audiogram (mean ± SD of CAP detection threshold as a function of stimulus frequency) from 5 WT (black symbols) and 5 Cx26 cKO (red symbols) mice. Solid horizontal lines indicate regions where CAP thresholds of WT and Cx26 cKO mice are significantly different (unpaired t-test, 0.05 two-tailed p value). (B) Threshold (0.2 nm) frequency tuning curves measured from the 54 kHz–59 kHz frequency region of the basal turn BM from 5WT, and 2 Cx26 cKO mice, anaesthetized and post-mortem. The frequency axes represent the stimulus frequency normalised to the characteristic frequency (CF) of the measurement location. Different symbols indicate different preparations. (C) Gain of BM displacement as a function of stimulus frequency (normalised to the CF of the measurement location) relative to malleus displacement for 4 WT mice. (D) BM phase as a function of stimulus frequency (normalised to the CF of the measurement location) measured from the 54 kHz–59 kHz frequency region of the basal turn BM from 5WT, and 5 Cx26 cKO mice, anaesthetized and post-mortem. All mice used in the study were 21–26 day post-partum.