Figure 1.

PFOS exhibits differential effects during different stages of mouse C. rodentium infection. (A) Wild-type mice were treated daily by oral gavage with DMSO or PFOS (2 mg/kg) in water for 7 days. Mice were then infected with 10¹⁰ Colony-forming unit (CFU) of C. rodentium. PFOS treatment continued on a daily basis through the whole time course of observation. Percentages of weight change of the two groups of mice before and after C. rodentium infection at indicated time points were shown. Data were pooled from 4 mice from each group. Error bars represent SEM. Data are representative of at least 3 independent experiments. (B) CFU counts of C. rodentium in the fecal pellets at indicated time points after infection were shown. Data were pooled from at least 4–8 mice from each group for all time points from two experiments. Error bars represent SEM. (C) CFU counts of C. rodentium from spleen and liver homogenates cultures at 21 days after infection were shown. Horizontal lines show the mean. Error bars represent SEM. The data are representative of three independent experiments.