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. 2017 Jul 12;7:5233. doi: 10.1038/s41598-017-05435-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Development of kidney fibrosis is aggravated in deltaF508 mice. (a) CFTR mutation aggravates kidney fibrosis manifestation in deltaF508 mice compared to wild type mice after UUO procedure. Collagen I staining and F4/80 staining; (b) Quantification analysis of Collagen I staining and F4/80 staining, representing mean ± SEM from three mice. *P < 0.05, **p < 0.01, ***p < 0.001 compared with wild type mice.