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. 2017 Jul 12;7:5258. doi: 10.1038/s41598-017-05579-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The geometric mean titers for sera from the identical and differing groups in the pandemic shift cohort are shown with standard deviations. The viruses used are listed on the x axis: BR/59, A/Brisbane/59/2007 (H1N1); CA/07, A/California/07/2009 (pdmH1N1); PR/16, A/Perth/16/2009 (H3N2); and BR/60, B/Brisbane/60/2008 (Victoria). The difference between the identical and differing groups was evaluated using the Mann Whitney rank test. n.s., not significant; *p ≤ 0.05; **p ≤ 0.01; and ***p ≤ 0.001.