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. 2017 Jul 12;7:5186. doi: 10.1038/s41598-017-05274-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MALAT1 expression and prognostic significance in pancreatic cancer. (A) LncRNAs that were overexpressed in all three available sets of gene profiling results and were associated with survival. (B) MALAT1 expression in normal pancreatic tissues and pancreatic tumour tissues from patients. (C) Relative expression levels of MALAT1 in patients with localized pancreatic tumours and patients with distant metastasis. (D) Kaplan–Meier plot showing the survival of patients with pancreatic cancer, according to whether such patients expressed high and low levels of MALAT1. (E) MALAT1 expression in pancreatic cancer cells, according to the array data. (F) MALAT1 expression in pancreatic cancer cells, as determined by reverse transcription and quantitative real-time PCR. (G) MALAT1 expression in normal pancreatic tissues and pancreatic tumour tissues from patients, as determined by in situ hybridization. H&E: Haematoxylin and eosin staining. Bar = 50 μm. (H) Reaction intensity was scored as undetectable or low (0), moderate (1) or strong (2).