Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 12;7:5186. doi: 10.1038/s41598-017-05274-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

MALAT1 knockdown inhibits cell proliferation. (A) MALAT1 mRNA expression after siRNA-mediated MALAT1 knockdown in pancreatic cancer cells (siCT: negative control, siMALAT1-1 and siMALAT1-2). (B) Cell growth in Aspc-1 and Panc1 cells, as determined by CCK8 assay (C) transfected with siRNAs. (D) Cell proliferation in Aspc-1 and Panc1 cells transfected with siRNAs, as determined by EdU assay. (E) Anchorage-independent growth of PDAC cells after MALAT1 downregulation. All the quantitative results in this study are presented as the mean ± standard error of the mean of at least three replicate determinations of each data point. *p < 0.05, **p < 0.01, ***p < 0.001 for siMALAT1 vs siCT.