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. 2017 Jul 12;7:5164. doi: 10.1038/s41598-017-05498-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Primitive erythroblasts undergo developmental-specific alternate splicing of Epb41 as they transition from BasoE at E10.5 to PolyE at E11.5. (A) Epb41, encoding protein 4.1 R, undergoes maturation-specific alternative splicing in definitive erythropoiesis. Epb41 exon 16 encodes a high spectrin-affinity domain and is exclusively incorporated into Epb41 transcripts in definitive erythroblasts at late maturational stages. Bars represent the location of the primer pairs used to detect Epb41 isoforms by RT-PCR. Constitutive exons are gray and alternatively spliced exons are white. (b) Splice variants of Epb41 in primitive erythroblasts during maturation were detected by RT-PCR. A representative analysis of 3 independent experiments is shown. Exons included in the bands are indicated in the right panel. M, DNA ladder.