Fig. 4.

Bacteria-induced ROS production is distinct from virus-dependent ROS mechanisms. a Phagosomal superoxide production to Haemophilus influenzae and Streptococcus pneumoniae as assessed by OxyBURST (100 μM) fluorescence microscopy in WT and TLR7^−/− immortalized bone marrow derived macrophages. Images are representative of >150 cells analyzed over each experiment. Original magnification ×100. b Is the quantification of the results (n = 5). All data are represented as mean ± S.E.M. One-way ANOVA followed by Dunnett’s post hoc test for multiple comparisons. *P < 0.05 compared to WT control. Scale bar: 10 µm