Table 1.
Expression of immune response-related genes in the chronic and persistent stages of tuberculosis infection by cDNA microarray analysis.
| Chronic/ persistent | Gene symbol | Gene description |
|---|---|---|
| 5.8 | Nos2 | nitric oxide synthase 2, inducible |
| 5.2 | LOC630751 | interferon-inducible GTPase 1-like |
| 5.2 | Ly6i | lymphocyte antigen 6 complex, locus I |
| 4.2 | Slamf8 | signaling lymphocytic activation molecule family member 8 |
| 3.6 | Tnf | tumor necrosis factor |
| 3.6 | Mmp12 | matrix metallopeptidase 12 |
| 3.5 | Cxcl10 | chemokine (C-X-C motif) ligand 10 |
| 3.4 | Cxcr6 | chemokine (C-X-C motif) receptor 6 |
| 3.2 | Ccr5 | chemokine (C-C motif) receptor 5 |
| 3.1 | Ccl8 | chemokine (C-C motif) ligand 8 |
| 3.0 | Xcr1 | chemokine (C motif) receptor 1 |
| 2.8 | Ifng | interferon gamma |
| 2.8 | Ccl19 | chemokine (C-C motif) ligand 19 |
| 2.8 | Slamf7 | signaling lymphocytic activation molecule family member 7 |
| 2.7 | Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 |
| 2.7 | Cd72 | CD72 antigen |
| 2.7 | Fcgr1 | Fc receptor, IgG, high affinity I |
| 2.7 | Ccl7 | chemokine (C-C motif) ligand 7 |
| 2.6 | Cxcl9 | chemokine (C-X-C motif) ligand 9 |
| 2.6 | Cd86 | CD86 antigen |
| 2.5 | Cd3e | CD3 antigen, epsilon polypeptide |
| 2.5 | Mmp13 | matrix metallopeptidase 13 |
| 2.5 | Cd4 | CD4 antigen |
| 2.5 | Ccl2 | chemokine (C-C motif) ligand 2 |
| 2.4 | Msr1 | macrophage scavenger receptor 1 |
| 2.4 | Cd3g | CD3 antigen, gamma polypeptide |
| 2.4 | Cd80 | CD80 antigen |
| 2.4 | Gm2023 | predicted gene 2023/ chemokine (C-C motif) ligand 19 |
| 2.4 | Cd6 | CD6 antigen |
| 2.4 | Cxcl11 | chemokine (C-X-C motif) ligand 11 |
| 2.3 | Ctss | cathepsin S |
| 2.3 | Ccl19 | chemokine (C-C motif) ligand 19 |
| 2.3 | Cd68 | CD68 antigen |
| 2.3 | Cxcl5 | chemokine (C-X-C motif) ligand 5 |
| 2.3 | Lck | lymphocyte protein tyrosine kinase |
| 2.2 | Ly9 | lymphocyte antigen 9 |
| 2.2 | Slamf6 | signaling lymphocytic activation molecule family member 6 |
| 2.2 | Socs1 | suppressor of cytokine signaling 1 |
| 2.2 | Itk | IL2 inducible T cell kinase |
| 2.2 | Ccl19 | chemokine (C-C motif) ligand 19 |
| 2.2 | Ccl19 | chemokine (C-C motif) ligand 19 |
| 2.2 | Cd5 | CD5 antigen |
| 2.2 | Cd40lg | CD40 ligand |
| 2.1 | Ccl20 | chemokine (C-C motif) ligand 20 |
| 2.1 | Cd52 | CD52 antigen |
| 2.1 | Cd8b1 | CD8 antigen, beta chain 1 |
| 2.1 | Il23r | interleukin 23 receptor |
| 2.1 | Slamf9 | signaling lymphocytic activation molecule family member 9 |
| 2.1 | Ccl12 | chemokine (C-C motif) ligand 12 |
| 2.0 | Cxcr3 | chemokine (C-X-C motif) receptor 3 |
| 2.0 | Il21r | interleukin 21 receptor |
| 2.0 | Lat | linker for activation of T cells |
For microarray analysis, a GeneChip® (Affymetrix) containing more than 698,000 total probes and 26,515 RefSeq (Entrez) genes was used. Among them, genes relevant to immune responses and increased more than 2-fold are shown.