FIGURE 12.

Cells treated with UTP exhibit a decrease in I_K potassium currents. Graphs show the mean I_K and I_A currents obtained by measuring the peak of each voltage step which were dissected by manipulating the holding potential. The I_A currents were determined by subtracting I_K currents from I_Tot currents. Insert shows the voltage steps protocol used to achieve voltage dependent potassium currents, V_h indicates holding potential. (A) Summary of data showing a decrease in I_K potassium currents initiated by UTP (p < 0.0001, n = 8). (B) I_A potassium currents were not significantly affected by UTP. (C) Shows a summary of results presenting a reduction in the evoked I_K currents (p < 0.0001, n = 3–5) in the presence of XE-991 alone and in combination with UTP. Symbols represent mean ± SEM.