Fig. 2.

Co-aggregation of pathological proteins in synapses may contribute to neurodegeneration. Synaptic toxicity of pathological proteins is thought to be one of the driving forces in several neurodegenerative diseases. In both a mouse model expressing fAD mutations in APP and PS1 and human wild-type τ ([65], top) and human AD brain (bottom), we observe colocalization of Aβ and τ at some synapses using the array tomography technique (arrows). Scale bars represent 5 µm in large panel and 2 µm in inset