Table 2.
Differences in stable weekly doses of warfarin among genotypes
| Genotype/Allele | Number of patients (%) | Stable weekly dose (mg) Mean ± SD | p value |
|---|---|---|---|
| VKORC1 -1639G > A | |||
| Genotype | |||
| GG | 7 (2.8) | 38.6 ± 8.0 | <0.001 |
| GA | 70 (28.0) | 27.9 ± 9.0 | |
| AA | 173 (69.2) | 19.4 ± 7.5 | |
| Allele | |||
| G | 84 (16.8) | - | - |
| A | 416 (83.2) | - | |
| CYP2C9 | |||
| Genotype | |||
| *1/*1 | 239 (95.6) | 22.6 ± 9.2 | 0.006 |
| *1/*3 | 10 (4.0) | 14.9 ± 5.3 | |
| *3/*3 | 1 (0.4) | 8.0 | |
| Allele | |||
| *1 | 488 (97.6) | - | - |
| *3 | 12 (2.4) | - | |
| CYP4F2 rs2108622 | |||
| Genotype | |||
| CC | 153 (61.2) | 22.2 ± 10.0 | 0.172 |
| CT | 81 (32.4) | 21.8 ± 7.4 | |
| TT | 16 (6.4) | 25.8 ± 8.4 | |
| Allele | |||
| C | 387 (77.4) | - | - |
| T | 113 (22.6) | - | |
| UGT1A1 rs887829 | |||
| Genotype | |||
| CC | 192 (76.8) | 22.0 ± 9.1 | 0.921 |
| CT | 56 (22.4) | 23.0 ± 9.6 | |
| TT | 2 (0.8) | 22.8 ± 17.3 | |
| Allele | |||
| C | 440 (88.0) | - | - |
| T | 60 (12.0) | - | |