Table 2.
Genotype/Allele | Number of patients (%) | Stable weekly dose (mg) Mean ± SD | p value |
---|---|---|---|
VKORC1 -1639G > A | |||
Genotype | |||
GG | 7 (2.8) | 38.6 ± 8.0 | <0.001 |
GA | 70 (28.0) | 27.9 ± 9.0 | |
AA | 173 (69.2) | 19.4 ± 7.5 | |
Allele | |||
G | 84 (16.8) | - | - |
A | 416 (83.2) | - | |
CYP2C9 | |||
Genotype | |||
*1/*1 | 239 (95.6) | 22.6 ± 9.2 | 0.006 |
*1/*3 | 10 (4.0) | 14.9 ± 5.3 | |
*3/*3 | 1 (0.4) | 8.0 | |
Allele | |||
*1 | 488 (97.6) | - | - |
*3 | 12 (2.4) | - | |
CYP4F2 rs2108622 | |||
Genotype | |||
CC | 153 (61.2) | 22.2 ± 10.0 | 0.172 |
CT | 81 (32.4) | 21.8 ± 7.4 | |
TT | 16 (6.4) | 25.8 ± 8.4 | |
Allele | |||
C | 387 (77.4) | - | - |
T | 113 (22.6) | - | |
UGT1A1 rs887829 | |||
Genotype | |||
CC | 192 (76.8) | 22.0 ± 9.1 | 0.921 |
CT | 56 (22.4) | 23.0 ± 9.6 | |
TT | 2 (0.8) | 22.8 ± 17.3 | |
Allele | |||
C | 440 (88.0) | - | - |
T | 60 (12.0) | - |