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. 2017 Feb 24;31(7):1502–1512. doi: 10.1038/leu.2017.36

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Network of Bcr–Abl interacting proteins. Common and differential interactors of Bcr–Abl p210 and p190 are shown and summarized in Supplementary Tables S4 and S5. Connections for the differential interactors are color-coded according to their log2 ratios (from ‘light red’ for a weak p210 enrichment to ‘dark red’ for a strong p210 enrichment; ‘light blue’ for a weak p190 enrichment to ‘dark blue’ for a strong p190 enrichment). Boxes around the individual proteins are color-coded according to the function and a red frame indicates that the protein was also found phosphorylated in the phosphoproteome analysis. Note that certain proteins enriched with either of the two Bcr–Abl isoforms can also interact with the other isoform and thus have a connection to both proteins.