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. 2017 Feb 24;31(7):1502–1512. doi: 10.1038/leu.2017.36

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Model of differential signaling networks of p210 and p190 Bcr–Abl. The main differences in Bcr–Abl interactors and phosphorylated proteins between p210 and p190 that we found, validated and discussed in this paper are summarized in this figure. As examples for common interactors/pY sites, the Ship2 phosphatase and the interaction of the Grb2/Sos complex with pY177 are shown. p210 shows stronger association with the Sts1 phosphatase and higher activation of the Stat5 transcription factor, as well as the Erk1/2 and Fyn/Lck kinases. p190 shows stronger association with the AP2 complex and clathrin, and higher activation of the Dok1 adaptor and the Lyn kinase.