Fig. 11.
Three-state folding and unfolded transitions of the SNARE complex (13). (A) Extension-time trajectory at a constant mean force of 17.4 pN. The red line shows the idealized extension trajectories derived from a three-state hidden Markov model. A close-up view of the region marked by a cyan box is shown. Data were mean-filtered to 1 kHz and plotted. (B) Probability density distribution of the extension shown in A. (C) Derived conformations of the three SNARE folding states and their energies.