Table 1.
Table of important Transcription Factors. Unless indicated the listed transcription factors are highly expressed in the specific populations. The gene name and protein names are how these genes are identified in the mouse genome, unless indicated as human.
| Population | Gene encoding Transcription Factor | Protein Name of Transcription Factor | Reference |
|---|---|---|---|
| MPEC (Memory Precursor Effector Cell) | Eomes | Eomesodermin | Banerjee et al. J. I. (2010) Pearce et al. Science (2003) Intlekofer et al. Nature Immunology (2005) |
| ID3 | ID3 | Ji et al. Nature Immunology (2011) Yang et al. Nature Immunology (2011) | |
| BCL-6 | BCL-6 | Yoshida et al. J. I. (2006) | |
| STAT3 | STAT3 | Cui et al. Immunity (2011) Siegel et al. Immunity (2011) | |
| FOXO1 | FOXO1 | Hess Michelini et al. J.E.M. (2013) Kim et al. Immunity (2013) | |
| Serpina3g | Spi2A | Liu et al. Nature Immunology (2004) | |
| TCF-7 | TCF-1 | Zhou et al. Immunity (2010) | |
| Memory (Effector and Central Memory combined) | Fos | Fos | Kaech et al. Cell (2002), Wherry et al. Immunity (2007) |
| ATF-2 | ATF-2 | Kaech et al. Cell (2002) | |
| ROR-α | ROR-α | Kaech et al. Cell (2002) | |
| Jun B | Jun B | Kaech et al. Cell (2002), Wherry et al. Immunity (2007) | |
| BHLHE40 | SHARP-2 | Wherry et al. Immunity (2007) | |
| Eomes | Eomesodermin | Wherry et al. Immunity (2007) | |
| Fosb | Fosb | Wherry et al. Immunity (2007) | |
| Hopx | Hop | Wherry et al. Immunity (2007) | |
| ID2 | ID2 | Wherry et al. Immunity (2007) | |
| Klf4 | Klf4 | Wherry et al. Immunity (2007) | |
| Runx2 | Runx2 | Wherry et al. Immunity (2007) | |
| Cebpb | Cebpb | Wherry et al. Immunity (2007) | |
| Myb (downregulated) | Myb | Wherry et al. Immunity (2007) | |
| TCM (Central Memory) | FasL | FasL | Dudani et al. J.I. (2008) |
| ID3 | ID3 | Yang et al. Nature Immunology (2011) | |
| Eomes | Eomesodermin | Banerjee et al. J.I. (2010) | |
| TCF-7 | TCF-1 | Zhou et al. Immunity (2010) | |
| Forced expression of Bcl-6 + inactivation of Tbx21, Prdm1 and ID2 | T-bet (Tbx21) Blimp-1 (Prdm1) | Cannarile, et al (2006 Ichii et al (2004) Intlekofer et al (2007) Rutishuaser et al. (2009) | |
| KLF2 | KLF2 | Skon et al. Nature Immunology (2013) | |
| TEM (Effector Memory) | Prdm1 [not necessary for maintenance of memory but required for efficient recall response; and migration of cells to the lung for influenza infection] | Blimp1 | Kallies et al. Immunity (2009) |
| KLF2 | KLF2 | Skon et al. Nature Immunology (2013) | |
| ASCL2 (human) | MASH2 or ASH2 | Hombrink et al. Nature Immunology (2016) | |
| RUNX1 (human) | Runx1 | Hombrink et al. Nature Immunology (2016) | |
| LEF1 (human) | TCF10 | Hombrink et al. Nature Immunology (2016) | |
| FOXP1 (human) | Foxp1 | Hombrink et al. Nature Immunology (2016) | |
| KLF12 (human) | AP2 repressor | Hombrink et al. Nature Immunology (2016) | |
| ZNF511 (human) | Znf511 | Hombrink et al. Nature Immunology (2016) | |
| IKZF5 (human) | Znfn1A5 or PEGASUS | Hombrink et al. Nature Immunology (2016) | |
| GTF2H2 (human) | TFIIH or BTF2 or P44 | Hombrink et al. Nature Immunology (2016) | |
| RERE (human) | Arp or Arg | Hombrink et al. Nature Immunology (2016) | |
| KLF7 (human) | Klf7 | Hombrink et al. Nature Immunology (2016) | |
| ZNF318 (human) | Zfp318 or Tzf | Hombrink et al. Nature Immunology (2016) | |
| TFDP2 (human) | Dp2 | Hombrink et al. Nature Immunology (2016) | |
| BBX (human) | HBP2 or ARTC1 | Hombrink et al. Nature Immunology (2016) | |
| HOXB7 (human) | Hox2 | Hombrink et al. Nature Immunology (2016) | |
| ZNF274 (human) | Zf2 or Zscan51 | Hombrink et al. Nature Immunology (2016) | |
| ZNF638 (human) | Np220 or Zfml | Hombrink et al. Nature Immunology (2016) | |
| ZNF365 (human) | Talanin or Uan | Hombrink et al. Nature Immunology (2016) | |
| EWSR1 (human) | Ews | Hombrink et al. Nature Immunology (2016) | |
| ZNF18 (human) | Zfp535 or Kox11 | Hombrink et al. Nature Immunology (2016) | |
| CNOT7 (human) | Hcaf-1 | Hombrink et al. Nature Immunology (2016) | |
| ZNF22 (human) | Zfp422 or Kox15 | Hombrink et al. Nature Immunology (2016) | |
| ZNF428 (human) | Zfp428 or C19orf37 | Hombrink et al. Nature Immunology (2016) | |
| FOXN3 (human) | C14orf116 or Ches1 | Hombrink et al. Nature Immunology (2016) | |
| ZNF83 (human) | Znf816B or HPF1 | Hombrink et al. Nature Immunology (2016) | |
| GTF3A (human) | TFIIIA or AP2 | Hombrink et al. Nature Immunology (2016) | |
| TRM (Resident memory) | Litaf | Litaf | Mackay et al. Nature Immunology (2013) |
| Nr4a1 | Nur77 | Mackay et al. Nature Immunology (2013); Hombrink et al. Nature Immunology (2016) | |
| Nr4a2 | Nurr1 | Mackay et al. Nature Immunology (2013) | |
| KLF2 (low levels) | KLF2 | Skon et al. Nature Immunology (2013) | |
| Zfp683 | Hobit | Mackay et al. Science (2015) | |
| ETS1 (human) | Ets-1 or EWSR2 | Hombrink et al. Nature Immunology (2016) | |
| ZFP36L1 (human) | Cmg1 or Brf1 | Hombrink et al. Nature Immunology (2016) | |
| GPBP1 (human) | Gpbp or Vasculin | Hombrink et al. Nature Immunology (2016) | |
| NFE2L2 (human) | NRF2 or HEBP1 | Hombrink et al. Nature Immunology (2016) | |
| RELA (human) | p65 or NFKB3 | Hombrink et al. Nature Immunology (2016) | |
| FOS (human) | Ap-1 or p55 | Hombrink et al. Nature Immunology (2016) | |
| NFAT5 (human) | NFAT5 | Hombrink et al. Nature Immunology (2016) | |
| ZC3H12A (human) | MCPIP | Hombrink et al. Nature Immunology (2016) | |
| NOTCH1 (human) | Notch1 | Hombrink et al. Nature Immunology (2016) | |
| MYB (human) | c-Myb | Hombrink et al. Nature Immunology (2016) | |
| KLF5 (human) | Klf5 OR Bteb2 | Hombrink et al. Nature Immunology (2016) | |
| CITED2 (human) | Mrg1 or VSD2 | Hombrink et al. Nature Immunology (2016) | |
| NR3C1 (human) | GRL | Hombrink et al. Nature Immunology (2016) | |
| REL (human) | c-Rel | Hombrink et al. Nature Immunology (2016) | |
| ZNF32 (human) | Kox30 | Hombrink et al. Nature Immunology (2016) | |
| AHR (human) | AhR or BHLHe76 | Hombrink et al. Nature Immunology (2016) | |
| TWIST1 (human) | Twist or BHLHa38 | Hombrink et al. Nature Immunology (2016) | |
| EPAS1 (human) | Epas-1 or Hif2alpha | Hombrink et al. Nature Immunology (2016) | |
| KLF6 (human) | Bcd1 or ST12 or COPEB | Hombrink et al. Nature Immunology (2016) | |
| NFKB1 (human) | EBP-1 or p50 | Hombrink et al. Nature Immunology (2016) | |
| CREM (human) | CDREM-2 or ICER | Hombrink et al. Nature Immunology (2016) | |
| NR4A3 (human) | Nor1 or Chn | Hombrink et al. Nature Immunology (2016) | |
| NFKB2 (human) | Lyt10 or H2TF1 or p52 | Hombrink et al. Nature Immunology (2016) | |
| BATF (human) | Batf or SFA2 | Hombrink et al. Nature Immunology (2016) | |
| IRF4 (human) | Irf4 | Hombrink et al. Nature Immunology (2016) | |
| RBPJ (human) | RBPJ Kappa or CSL or SUH | Hombrink et al. Nature Immunology (2016) | |
| PBX4 (human) | Pbx4 | Hombrink et al. Nature Immunology (2016) | |
| ATF3 (human) | Atf3 | Hombrink et al. Nature Immunology (2016) | |
| FOSB (human) | FosB or AP-1 | Hombrink et al. Nature Immunology (2016) | |
| BACH2 (human) | Bach2 | Hombrink et al. Nature Immunology (2016) | |
| RUNX3 (human) | Runx3 or CBFA3 | Hombrink et al. Nature Immunology (2016) | |
| EGR2 (human) | Egr2 or Krox20 | Hombrink et al. Nature Immunology (2016) |