Table 1. Crystallographic data and refinement statistics.

Ligand	NADH+oxaloacetate	Malonate
Space group	P21	P21
Cell dimensions
a, b, c (Å)	72.373, 138.763, 74.567	70.806, 76.952,118.858
α, β, γ (o)	90, 110.12, 90	90, 96.48, 90.0
Resolution (Å)	1.87	1.58
Rmerge, %	10.3 (75.1)	6.9 (100.2)
Total number of observations	741,462 (42,498)	318,978 (18,851)
Unique reflections	112,079 (7,366)	155,035 (9,932)
Completeness, (outer shell)%	98.9 (87.7)	89.7 (78.5)
I/σI (outer shell)	14.00 (2.70)	8.00 (0.80)
<I> half-set correlation	99.7 (56.9)	99.7 (33.4)
Reflections used for refinement	112,037	147,320
Geometry: Ramachandran favoured, allowed, outliers, %	98.18, 1.82, 0.0	98.18, 1.82, 0.0
Rms deviation from ideal values for bond lengths (Å) and bond angles (o)	0.012/1.227	0.018/1.734
Number of non-hydrogen atoms in refinement	11,166	11,632
Refinement (R/Rfree 5% reflections in test set), %	17.00/19.90	17.40/20.30