Fig. 1.

Concentration–response data for AICP and DCS at human NMDA receptor subtypes. (A) Chemical structures of agonists at the GluN1 glycine binding site. (B) Representative recordings of concentration–response data for AICP in the presence of 100 µM glutamate at recombinant human GluN1/2A and GluN1/2C receptors. (C, D) Concentration–response data for (C) AICP and (D) DCS at human NMDA receptor subtypes in the presence of 100 µM glutamate. Data are mean ± S.D. from 4 to 15 oocytes and are normalized to the maximal response to glycine (100 µM) measured in the same recording. The EC₅₀ values and relative agonist efficacy (i.e., maximal responses relative to glycine) are listed in Table 1.