Table 1.

Physiological variables during phrenic nerve recordings

Condition	Treatment	Body temperature (°C)	pH	PaCO2 (mmHg)	PaO2 (mmHg)	SBE (mEq*L−1)	MAP (mmHg)
Physiological variables for cycling and OVX females
Baseline	Time control	37.8 ± 0.1	7.350 ± 0.012	49 ± 1	320 ± 7	1.06 ± 0.87	108 ± 7
	Proestrus	37.3 ± 0.1	7.341 ± 0.015	47 ± 2	335 ± 6	−0.55 ± 0.52	125 ± 3
	Estrus	37.2 ± 0.1	7.309 ± 0.008	51 ± 1	339 ± 8	−0.60 ± 0.34	117 ± 7
	OVX	38.0 ± 0.3	7.338 ± 0.010	49 ± 2	319 ± 2	0.11 ± 0.63	118 ± 4
	OVX+E	37.9 ± 0.1	7.353 ± 0.008	49 ± 1	316 ± 10	1.46 ± 0.45	115 ± 5
Hypoxia	Time control (no hypoxia)	37.8 ± 0.1	7.346 ± 0.014	49 ± 1	322 ± 6*	1.16 ± 0.92	109 ± 8
	Proestrus	37.2 ± 0.1f	7.329 ± 0.015	47 ± 2	41 ± 2#	−1.36 ± 0.48	91 ± 10c
	Estrus	37.2 ± 0.1f	7.304 ± 0.011	51 ± 2	39 ± 1#	−1.00 ± 0.38	95 ± 6b
	OVX	38.2 ± 0.4	6.825 ± 0.494	50 ± 2	40 ± 1#	−0.33 ± 0.38	85 ± 9#
	OVX+E	37.8 ± 0.1	7.343 ± 0.011	49 ± 2	42 ± 1#	0.66 ± 0.56	64 ± 9#
60 min	Time control	37.8 ± 0.3	7.347 ± 0.011	48 ± 1e	320 ± 5	0.36 ± 0.92e	107 ± 5
	Proestrus	37.5 ± 0.2	7.333 ± 0.010	47 ± 2	308 ± 11b	−1.13 ± 0.35	105 ± 7a
	Estrus	37.3 ± 0.1	7.318 ± 0.008	51 ± 2	325 ± 6	0.03 ± 0.30	111 ± 5d
	OVX	37.9 ± 0.3	7.353 ± 0.013	49 ± 2	320 ± 6	1.19 ± 0.54	103 ± 5a
	OVX+E	38.1 ± 0.2d	7.344 ± 0.009	49 ± 1	320 ± 9	0.66 ± 0.24	96 ± 5c
Physiological variables for OVX and E2-BSA females
Baseline	Time control	37.6 ± 0.1	7.332 ± 0.016	48 ± 1	306 ± 4	−0.57 ± 1.03	73 ± 4
	BSA	37.6 ± 0.2	7.327 ± 0.007	50 ± 2	287 ± 19	−0.08 ± 0.94	68 ± 4
	E2-BSA	37.8 ± 0.1	7.341 ± 0.010	49 ± 2	290 ± 10	0.78 ± 0.83	76 ± 6
Hypoxia	Time control (no hypoxia)	37.5 ± 0.1	7.334 ± 0.016	47 ± 1	312 ± 4*	−0.57 ± 0.90	74 ± 3*
	BSA	37.4 ± 0.2a	7.313 ± 0.011	51 ± 2	42 ± 1#	−0.44 ± 0.56	21 ± 8#
	E2-BSA	37.4 ± 0.1#	7.325 ± 0.015	50 ± 2	41 ± 1#	−0.20 ± 0.66	23 ± 2#
60 min	Time control	37.5 ± 0.1	7.335 ± 0.017	49 ± 2	315 ± 10	−0.03 ± 0.95	73 ± 5
	BSA	37.5 ± 0.2	7.318 ± 0.015	49 ± 3	307 ± 10	−0.86 ± 0.66	61 ± 4
	E2-BSA	37.9 ± 0.1	7.332 ± 0.012	50 ± 2	294 ± 8	0.24 ± 0.88	66 ± 6

Values are means ± SEM for body temperature, pH, PaCO₂, PaO₂, SBE, and MAP for each group during baseline, hypoxia, and 60 min post-aIH conditions. All variables remained within standard de novo criteria within each treatment group and across each condition.

^ap < 0.05;

^bp < 0.01;

^cp < 0.001 versus same treatment in baseline;

^dp < 0.05;

^ep < 0.01 versus same treatment in hypoxia condition;

^fp < 0.01 versus OVX in same condition;

*p < 0.001 versus other treatments in hypoxia condition;

#p < 0.001 versus same treatment in both baseline and 60 min conditions.