Table 1.
Baseline data in all 49 dogs
| Variable (unit) | Benazepril (n = 24) | Placebo (n = 25) | P value |
|---|---|---|---|
| Median (range) or n | Median (range) or n | ||
| Age (year) | 10.2 (1.3–19.0) | 11.0 (0.58–18.0) | .89 |
| Body weight (kg) | 21.3 (4.3–38.0) | 18.0 (2.5–41.9) | .60 |
| Sexa | .38 | ||
| Entire female | 5 | 4 | |
| Neutered female | 7 | 4 | |
| Entire male | 2 | 1 | |
| Neutered male | 9 | 16 | |
| IRIS Stage | .68 | ||
| 2 | 6 | 6 | |
| 3 | 13 | 16 | |
| 4 | 5 | 3 | |
| Plasma chemistry | |||
| Calcium [mmol/L] | 2.4 (2.1–3.1) | 2.5 (2.1–2.8) | .25 |
| Creatinine [μmol/L] | 282.9 (88.4–671.8) | 229.8 (97.2–610.0) | .60 |
| Phosphate [mmol/L] | 1.6 (1.1–5.8) | 1.6 (0.84–3.0) | .88 |
| Potassium [mmol/L] | 4.7 (3.9–6.1) | 4.9 (3.4–6.6) | .67 |
| Sodium [mmol/L] | 141.5 (133.0–152.0) | 142.0 (133.0–152.0) | .88 |
| Total protein [g/L] | 69.0 (53.7–86.0) | 66.0 (57.5–110.0) | .21 |
| Urea [mmol/L] | 47.7 (10.7–164.2) | 50.0 (6.6–171.4) | .94 |
| ALP [IU/L] | 41.0 (18.0–123.0) | 47.0 (10.0–176.0) | .82 |
| ALT [IU/L] | 37.5 (13.0–222.3) | 35.0 (7.0–103.4) | .91 |
| Blood hematology | |||
| RBC [1012/L] | 5.2 (3.2–6.9) | 5.1 (2.5–8.0) | .92 |
| WBC [109/L] | 9.1 (5.3–21.1) | 9.5 (3.2–21.6) | .92 |
| Urine | |||
| UPC | 1.2 (0.21–17.5) | 1.3 (0.11–18.0) | .44 |
| USG | 1.013 (1.006–1.020) | 1.014 (1.009–1.022) | .78 |
a
The neutered status of 1 male dog in the benazepril group was not recorded.
P values were calculated with the Mann‐Whitney U, Kruskal‐Wallis, or Fisher's exact tests.