Table 2.
Reasons for premature withdrawal of dogs from the study
| Reason | Benazepril (n = 24) | Placebo (n = 25) | P value |
|---|---|---|---|
| N (%) | N (%) | ||
| Need for administration of parenteral fluids related to renal failurea | 8 (33.3) | 6 (24.0) | .54 |
| Euthanasia related to renal failurea | 7 (29.2) | 11 (44.0) | .38 |
| Death related to renal failurea | 0 (0.0) | 0 (0.0) | 1.0 |
| Serious adverse event | 14 (58.3) | 12 (48.0) | .57 |
| Increase in plasma creatinine concentration | 9 (37.5) | 4 (16.0) | .11 |
| Decision by investigator | 5 (20.8) | 4 (16.0) | .73 |
| Other reason | 5 (20.8) | 5 (20.0) | 1.0 |
| Failure of cooperation or compliance | 1 (4.2) | 3 (12.0) | .61 |
| Failure to administer test treatment | 0 (0.0) | 2 (8.0) | .49 |
| Decision to stop the trial by the sponsor | 0 (0.0) | 2 (8.0) | .49 |
| Withdrawal of owner's consent | 0 (0.0) | 0 (0.0) | 1.0 |
a
The primary endpoint, treatment failure, was a composite of these 3 variables.
Dogs could be classified in more than one category.
P values were calculated with Fisher's exact test.