Table 1.
Outcomes of pilot studies of tolerance induction for living donor kidney transplantation in Stanford, Northwestern and Massachusetts General Hospital (MGH)
| Stanford | Northwestern | MGH | ||
|---|---|---|---|---|
| HLA | Matched | Mismatched | Mismatched | |
| Number | 22 | 31 | 12* | |
| Off immunosuppression | 17 † | 16 | 8 | |
| Death (related directly to the regimen) | 0 | 1 ‡ | 0 | |
| Rejection | 3 | 3 | 3 § | |
| GVHD | 0 | 2 | 0 | |
| Chimerism | ||||
| Induction | 21 | 30 | 11 | |
| Transient | 9 | 5 | 11 | |
| Stable mix | 7 | 3 | 0 | |
| Full | 0 | 16 | 0 | |
*10 patients received the cyclophosphamide‐based conditioning regimen and two received total body irradiation (TBI)‐based regimen. †One patient is in the midst of immunosuppressive drug tapering. ‡One patient died due to graft‐versus‐host disease (GVHD). §Two patients developed chronic rejection after 5 and 8 years. One patient developed acute rejection at 9 months. HLA = human leucocyte antigen.