Table 3.
Clinicopathologic findings among outcome in dogs with chronic diarrhea
| Variable (reference range) | Complete remission (n = 68) | Partial remission (n = 43) | No remission (n = 16) | P valueb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median (n) | Range | L/E (n) | Median (n) | Range | L/E (n) | Median (n) | Range | L/E (n) | ||
| Leukocytes (6,000–12,000/μL) | 10,510 (68) | 4,010–20,620 | 6/27 | 10,140 (43) | 5,820–50,290 | 1/16 | 10,240 (16) | 7,010–45,720 | 0/5 | .906 |
| Hematocrit (44–55%)a | 47.3a (68) | 30.9–62.9 | 16/8 | 45.6a (43) | 30.1–56.0 | 12/1 | 38.1b (16) | 25.2–48.1 | 13/0 | <.001 |
| Platelets (165–400 G/L) | 260 (68) | 149–1,205 | 3/10 | 239 (43) | 131–760 | 4/4 | 305 (16) | 78–443 | 3/2 | .207 |
| Neutrophils (3,000–9,000/μL) | 7,320 (66) | 6,936–17,939 | 5/19 | 6,794 (41) | 2,328–41,238 | 2/14 | 7031 (16) | 4,673–39,319 | 0/6 | .803 |
| Eosinophils (<600/μL) | 252 (64) | 0–1,789 | –/16 | 503 (41) | 0–2,961 | –/16 | 282 (16) | 0–1,656 | –/5 | .209 |
| Lymphocytes (1,000–3,600/μL) | 1,889 (64) | 206–6,161 | 11/8 | 1,991 (41) | 137–4,844 | 7/4 | 1796 (16) | 231–45,180 | 5/2 | .899 |
| Monocytes (<500/μL) | 540 (61) | 65–2,526 | –/33 | 608 (41) | 0–3,520 | –/24 | 496 (16) | 230–1,841 | –/8 | .674 |
| Protein (5.4–6.6 g/dL) | 6.11 (68) | 3.57–7.36 | 13/13 | 5.97 (43) | 2.88–8.08 | 10/10 | 5.64 (16) | 2.70–7.65 | 7/2 | .212 |
| Albumin (2.8–3.6 g/dL)a | 2.96a (67) | 1.70–3.64 | 21/1 | 2.85a (42) | 1.39–3.60 | 18/0 | 2.44b (16) | 1.17–3.17 | 11/0 | .001 |
| Calcium, total (2.5–2.9 mmol/L)a | 2.7a (64) | 1.8–3.1 | 9/7 | 2.7a (43) | 1.5–3.3 | 10/4 | 2.5b (16) | 2.0–2.8 | 7/0 | .025 |
| Phosphorus (0.96–1.6 mmol/l) | 1.21 (66) | 0.40–2.40 | 13/12 | 1.33 (42) | 0.84–2.79 | 5/9 | 1.32 (16) | 0.66–1.92 | 2/2 | .403 |
| Urea (21–60 mg/dL) | 35.3 (65) | 14.5–83.4 | 8/4 | 36.0 (43) | 19.3–112.3 | 2/5 | 45.9 (16) | 17.1–156.0 | 2/3 | .371 |
| Creatinine (0.6–1.4 mg/dL) | 0.91 (64) | 0.50–1.34 | 4/0 | 0.97 (42) | 0.49–2.26 | 2/3 | 0.96 (16) | 0.63–1.93 | 0/1 | .205 |
| Glucose (81–112 mg/dL) | 102 (66) | 76–135 | 1/16 | 99 (42) | 71–138 | 4/9 | 106 (16) | 76–152 | 2/2 | .531 |
| Sodium (140–150 mmol/L) | 146 (67) | 138–155 | 1/6 | 146 (42) | 127–159 | 1/3 | 147 (16) | 131–154 | 2/3 | .904 |
| Potassium (3.6–4.8 mmol/L) | 3.95 (67) | 2.93–4.93 | 7/2 | 3.93 (41) | 3.37–5.10 | 4/2 | 4.25 (16) | 3.69–4.84 | 0/1 | .147 |
| Alanine aminotransferase (<76 U/L) | 52 (66) | 11–371 | –/19 | 46 (43) | 19–362 | –/11 | 51 (16) | 6–121 | –/5 | .616 |
| Alkaline phosphatase (<97 U/L) | 47 (65) | 7–1,582 | –/11 | 43 (43) | 9–1,412 | –/11 | 65 (16) | 12–279 | –/7 | .204 |
| Aspartate aminotransferase (<41 U/L) | 26 (65) | 7–120 | –/6 | 27 (42) | 5–69 | –/8 | 30 (16) | 8–153 | –/5 | .233 |
| Cobalamin (300–800 pg/mL)a | 319a (63) | 118–2,000 | 28/2 | 317a,b (43) | 125–864 | 17/1 | 160b (11) | 83–536 | 7/0 | .025 |
| Folic acid (3–10 ng/mL) | 12.1 (60) | 4.3–24.0 | 0/40 | 10.1 (36) | 2.2–24.0 | 1/18 | 11.3 (11) | 4.9–17.8 | 0/8 | .439 |
a
Significance < .05.
b
P values based on Kruskal‐Wallis comparison of differences among medians. Medians without superscripts in common are statistically different based on Mann‐Whitney U‐tests and Bonferroni adjustment for multiple comparisons. E, blood value elevated (above reference range); L, blood value lowered (below reference range).