Table 4.
Selected clinicopathologic findings associated with poor clinical outcome compared among localization and among selected diagnoses in dogs with chronic diarrhea
| Group | Hematocrit (44‐55%) | Albumin (2.8‐3.6 g/dL) | Calcium, total (2.5‐2.9 mmol/L) | Cobalamin (300‐800 pg/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (n) | Range | L/E (n) | Median (n) | Range | L/E (n) | Median (n) | Range | L/E (n) | Median (n) | Range | L/E (n) | |
| Localization (P valuea) | .009 | .010 | .027 | .003 | ||||||||
| SI | 44.6a (42) | 25.2–60.5 | 18/2 | 2.75a (41) | 1.49–3.55 | 23/0 | 2.6a (41) | 2.0–3.1 | 15/3 | 229a (39) | 83–2,000 | 26/2 |
| LI | 46.9a,b (36) | 33.6–59.0 | 14/2 | 2.95b (36) | 2.27–3.64 | 12/1 | 2.8b (34) | 2.4–3.0 | 2/4 | 359b (33) | 154–702 | 7/0 |
| DI | 48.1b (49) | 31.7–62.9 | 9/5 | 2.98b (48) | 1.17–3.60 | 15/0 | 2.7a,b (48) | 1.5–3.3 | 9/4 | 319b (45) | 125–864 | 19/1 |
| PE vs. SE (P valuea) | .665 | .373 | .509 | .600 | ||||||||
| PE | 46.6 (123) | 15.0–62.9 | 40/8 | 2.87 (121) | 1.17–3.64 | 49/1 | 2.66 (119) | 1.46–3.25 | 27/9 | 312 (115) | 83–2,000 | 51/3 |
| SE | 45.2 (13) | 30.1–59.8 | 5/2 | 3.01 (13) | 2.06–3.26 | 4/0 | 2.62 (13) | 2.40–2.93 | 2/2 | 248 (9) | 169–450 | 5/0 |
| Selected diagnoses with PE (P valuea) | <.001 | <.001 | .001 | .224 | ||||||||
| FRE | 47.9a (64) | 39.2–62.9 | 11/6 | 2.99a (62) | 1.70–3.64 | 17/1 | 2.72a (61) | 1.82–3.14 | 8/7 | 303 (63) | 118–864 | 31/1 |
| ARE | 45.6a,b (11) | 39.4–59.0 | 5/1 | 2.92a,b (11) | 1.62–3.26 | 4/0 | 2.64a,b (11) | 2.08–2.81 | 2/0 | 353 (11) | 154–898 | 3/1 |
| IBD | 41.9b (22) | 30.3–54.2 | 13/0 | 2.22b (22) | 1.17–3.21 | 15/0 | 2.43b (22) | 1.46–3.25 | 11/1 | 297 (20) | 83–702 | 11/0 |
| LYM | 33.0b (5) | 25.2–47.1 | 4/0 | 2.80a,b (5) | 2.16–3.17 | 2/0 | 2.59a,b (5) | 2.23–2.67 | 2/0 | 311 (3)* | 225–312 | 1/0 |
| Giardia | 49.7a,b (15) | 15.0–55.9 | 3/1 | 2.88a (15) | 2.29–3.42 | 5/0 | 2.74a (14) | 2.40–2.93 | 2/1 | 366 (14) | 108–2,000 | 3/1 |
| Selected diagnoses with SEb | ||||||||||||
| EPI | 41.8 (4) | 30.9–45.2 | 3/0 | 2.81 (4) | 2.29–3.24 | 2/0 | 2.58 (4) | 2.44–2.78 | 1/0 | 224 (4) | 169–308 | 3/0 |
| CP | 47.2 (3) | 44.3–59.8 | 0/1 | 2.87 (3) | 2.43–3.26 | 1/0 | 2.61 (3) | 2.52–2.93 | 0/1 | 233 (1) | – | 1/– |
P values based on Kruskal‐Wallis comparison of differences among medians. Medians without superscripts in common are statistically different based on Mann‐Whitney U‐tests and Bonferroni adjustment for multiple comparisons. Significance < .05.
Data for selected diagnoses with a group size of 3 or 4 dogs were descriptively analyzed. L, blood value lowered (below reference range); E, blood value elevated (above reference range); SI, small intestinal disease; LI, large intestinal disease; DI, diffuse intestinal disease; PE, primary enteropathy (gastrointestinal disease); SE, secondary enteropathy (extragastrointestinal disease); FRE, food responsive enteropathy; ARE, antibiotic responsive enteropathy; IBD, idiopathic inflammatory bowel disease; LYM, intestinal lymphoma; Giardia, infection with Giardia spp.; EPI, exocrine pancreatic insufficiency; CP, chronic pancreatitis.