Table 1.
Differences in selected mouse characteristics (mean ± SD) at sacrifice between non-diabetic and diabetic mice as well as the dose-response relationship between continuous insulin dose and each characteristic.
| Characteristic | No treatment |
STZ-T1D insulin dose (IU/day) |
Linear regression |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-T1D | STZ-T1D | p-Value | 0 | 0.0625 | 0.125 | 0.25 | Slopea (p-value) | R2 (%) | |
| Body weight (g) | 27.8 ± 4.1 | 20.9 ± 1.2 | < 0.001 | 22.7 ± 1.7 | 25.0 ± 1.0 | 24.9 ± 1.8 | 26.8 ± 0.9 | 14.8 (< 0.001) | 54.6 |
| Glucose (mg/dl) | 139 ± 19 | 535 ± 63 | < 0.001 | 595 ± 10 | 562 ± 28 | 449 ± 32 | 209 ± 119 | − 1626 (< 0.001) | 84.3 |
| RatLAPS (ng/ml) | 14.5 ± 5.3 | 35.4 ± 11.1 | 0.001 | 39.9 ± 18.6 | 46.6 ± 2.0 | 39.5 ± 13.6 | 25.4 ± 7.0 | − 71.0 (0.033) | 25.4 |
| P1NP (ng/ml) | 48.9 ± 4.6 | 18.6 ± 4.5 | < 0.001 | 26.6 ± 11.5 | 29.5 ± 5.5 | 39.1 ± 6.9 | 63.3 ± 23.7 | 155 (0.001) | 54.7 |
a
Slope is the change in characteristic per change in dose as determined by linear regression of each characteristic value vs. dose (i.e., not the mean value vs. dose).