Table 2.
Differences in selected properties (mean ± SD) of the femur between non-diabetic and diabetic mice as well as the dose-response relationship between continuous insulin dose and each characteristic.
| Property | No treatment |
STZ-T1D insulin dose (IU/day) |
Linear regression |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-T1D | STZ-T1D | p-Value | 0 | 0.0625 | 0.125 | 0.25 | Slopea (p-value) | R2 (%) | |
| Lengthb (mm) | 14.0 ± 0.4 | 13.7 ± 0.3 | 0.146 | 13.7 ± 0.2 | 13.9 ± 0.2 | 13.9 ± 0.2 | 14.0 ± 0.1 | 0.95 (0.016) | 21.9 |
| Ps.Pm (mm) | 4.17 ± 0.25 | 4.00 ± 0.09 | 0.036 | 4.08 ± 0.10 | 4.16 ± 0.07 | 4.12 ± 0.08 | 4.31 ± 0.11 | 0.86 (0.001) | 43.7 |
| Es.Pm (mm) | 2.59 ± 0.19 | 2.67 ± 0.09 | 0.203 | 2.71 ± 0.06 | 2.73 ± 0.08 | 2.56 ± 0.09 | 2.68 ± 0.09 | = 0 (0.469) | 2.6 |
| Ct.Th (μm) | 199 ± 7 | 176 ± 9 | < 0.001 | 179 ± 2 | 182 ± 3 | 186 ± 7 | 193 ± 6 | 55 (< 0.001) | 54.5 |
| Ct.TMD (mgHA/cm3) | 1365 ± 8 | 1373 ± 10 | 0.087 | 1389 ± 5 | 1368 ± 18 | 1379 ± 7 | 1377 ± 10 | = 0 (0.500) | 2.5 |
| Modulus (GPa) | 16.6 ± 3.0 | 18.5 ± 2.8 | 0.180 | 16.1 ± 1.9 | 17.2 ± 2.2 | 17.9 ± 0.7 | 17.3 ± 0.7 | = 0 (0.260) | 6.8 |
| Bending strength (MPa) | 285 ± 19 | 262 ± 15 | 0.022 | 274 ± 17 | 272 ± 17 | 284 ± 19 | 278 ± 14 | = 0 (0.505) | 2.3 |
| Toughness (MJ/m3) | 2.12 ± 0.48 | 2.45 ± 0.91 | 0.310 | 1.96 ± 0.82 | 1.81 ± 0.29 | 2.00 ± 0.31 | 2.51 ± 0.67 | = 0 (0.122) | 17.5 |
a
Slope is the change in property per change in dose as determined by linear regression of each property value vs. dose.
b
Distance between the intercondyler groove and femoral neck as determined by calipers.