Differential expression of RNA classes in idiopathic disease. A, Distribution of RNA classes, novel IncRNAs, known IncRNAs, and mRNAs, determined by RNA-seq. B, ‘Volcano plots’ showing differential expression of different RNA classes in MS-E compared to CTRL. C, Numbers of over- and under-expressed novel IncRNAs, known IncRNAs. and mRNAs in different idiopathic disease cohorts after FDR correction. D, Hierarchical clustering of RNA classes across idiopathic disease cohorts after FDR correction.