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. Author manuscript; available in PMC: 2017 Oct 24.
Published in final edited form as: Nat Genet. 2017 Apr 24;49(6):866–875. doi: 10.1038/ng.3854

Fig. 5. SYNCRIP regulates the myeloid leukemia stem cell gene expression program.

Fig. 5

(a) Gene expression heat map of the top 191 upregulated and downregulated genes from RNA-sequencing analysis of MLL-AF9 leukemia cells transduced with control and shRNAs against Syncrip. n=3 biological replicates. (b–i) GSEA analysis showing gene expression signature (b–c) genes enriched in hematopoietic stem cells and leukemic stem cells (d) genes upregulated in myeloid development program enriched in Syncrip-KD cells (e–f) MLL-AF9 directed taget genes and (g) HOXA9-MEIS1 target genes downregulated in Syncrip-KD cells (h–i) enrichment of MSI2 target genes in SYNCRIP regulated genes.

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