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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Feb 13;27(6):1356–1359. doi: 10.1016/j.bmcl.2017.02.020

Figure 2.

Figure 2

Summary of unproductive SAR with the M5 NAM ML375 (1, VU0483253). Only fluoro substituents retained activity, but led to higher clogPs and very poor physiochemical properties.