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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Feb 13;27(6):1356–1359. doi: 10.1016/j.bmcl.2017.02.020

Figure 3. Molecular pharmacology profile of M5 NAMs 9–11.

Figure 3

A) hM5 concentration response curves (CRCs) for 9, 10 and 11; B) mAChR CRCs for hM1–5, highlighting the exquisite selectivity for (S)-11 as an M5 NAM, as well as rat M5, showing no significant species differences. Data represent means from at least three independent determinations performed in triplicate via intracellular calcium mobilization assays in recombinant Chinese Hamster Ovary (CHO) cells stably transfected with the individual mAChRs.