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. Author manuscript; available in PMC: 2018 Mar 15.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Feb 13;27(6):1356–1359. doi: 10.1016/j.bmcl.2017.02.020

Scheme 1.

Scheme 1

Synthesis of M5 NAM analogs 4.a

aReagents and conditions: (a) HNR1R2 (3.0 equiv.), 5 mol% Pd(OAc)2, 15 mol% SPhos, toluene (0.25 M), microwave, 20 min, 45–92%.