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. 2017 Jul 13;14:19. doi: 10.1186/s12987-017-0067-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a Therapeutic application of encapsulated cells. Encapsulated cells are protected by a membrane or capsular matrix that allows nutrients, waste, and therapeutic products to pass freely but also works as a barrier to immune cells. Capsules can be transplanted into the brain for the treatment of brain diseases. b Subcommissural organ (SCO) secretory explants stained in bloc with AFRU (red) and caveolin-1 (green) displaying extracellular material (arrows) on the surface of cells. c Secretory SCO-explants encapsulated within a microsphere. Haematoxylin and eosin stain. Scale bars b 30 µm; c 160 µm