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. Author manuscript; available in PMC: 2017 Jul 13.
Published in final edited form as: Drug Deliv Transl Res. 2016 Jun;6(3):225–233. doi: 10.1007/s13346-016-0294-y

Figure 1. Factors affecting the delivery of nanoparticles.

Figure 1

A schematic of the cerebral capillary lumen is shown. Shear stress and hydrodynamic forces tend to displace nanoparticles from the endothelium. Nanoparticle properties including shape, size, and charge as well as ligand-receptor interactions determine the affinity of the particles to attach to the endothelium.