Biochemical s of dengue-positive cases according to the clinical classification and epidemic, Campos dos Goytacazes, Rio de Janeiro, Brazil. (A) AST and (B) ALT. SD/2010 () and SD/2013 (). AST = aspartate aminotransferase; ALT = alanine aminotransferase; DwoWS: dengue without warning signs; DwWS = dengue with warning signs; OFD = other febrile disease; SD = severe dengue. P values * < 0.05, ** < 0.01, *** < 0.001, and **** < 0.0001 were considered statistically significant.