Figure 4.

Persisting parasite signal in the absence of gametocytemia in clinical trial samples. Prevalence of (A–B) total parasites and (C–E) ring-stage trophozoites of clinical malaria trial samples that was negative for gametocyte transcripts (Pfs25). Presented in the bar graphs is the prevalence of the signal with the different markers in different days since treatment, in the three treatment arms. (F–J) Box plots indicate the median, 25th and 75th percentile parasite densities (Log₁₀ parasites/mL) of the markers in the three treatments arms. Whiskers indicate the 5th and 95th percentiles. The three treatment groups are presented on the x axis: AL = only artemether–lumefantrine, 0.25 = AL + 0.25 mg/kg primaquine, and 0.40 = AL + 0.40 mg/kg primaquine. Shading of bars and whiskers indicates days since the start of treatment (days 3–14), dark to light colors. Error bars indicate the upper limit of the 95% confidence interval of a binomial distribution.