Table 3.
Asexual parasite densities estimated by SBP1 on days 7, 10, and 14 after initiation of treatment
Treatment arm | Days since treatment | N | Median (25th–75th percentiles) | P value |
---|---|---|---|---|
Combined | 14 | 53 | 1,741.8 (805.4–6025.6) | |
10 | 41 | 668.3 (309.7–1710.0) | 0.0062 | |
7 | 43 | 1,074 (323.4–2,275.1) | 0.0162 | |
AL | 14 | 10 | 1,706.1 (1,081.4–2,296.1) | |
10 | 5 | 447.7 (291.7–937.6) | 0.1171 | |
7 | 8 | 817 (308.1–2,895.1) | 0.778 | |
AL + 0.25 mg PQ | 14 | 22 | 2,230.8 (409.3–3,033.9) | |
10 | 20 | 670 (439.6–1,565.1) | 0.1341 | |
7 | 17 | 1,074 (339.6–1,798.9) | 0.2345 | |
AL + 0.40 mg PQ | 14 | 21 | 1,990.7 (977.2–10,568.2) | |
10 | 16 | 887.5 (220.6–2,338.9) | 0.0385 | |
7 | 18 | 1,087.9 (282.5–1,584.9) | 0.0408 |
AL = artemether/lumefantrine; N = number of samples positive for SBP1; PQ = primaquine; SBP1 = skeleton-binding protein 1. Density is expressed as estimated number of parasites per milliliter of blood. The P value reflects the difference in density between day 14 and days 7 and 10.