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. Author manuscript; available in PMC: 2018 Mar 14.
Published in final edited form as: Biochemistry. 2017 Mar 3;56(10):1529–1535. doi: 10.1021/acs.biochem.6b01125

Figure 4.

Figure 4

A comparison of inhibition of cross-linking from the 15N{13C} REDOR difference spectra of whole cells of S. aureus grown in media containing [15N]glycine and D-[1-13C]alanine, plus therapeutic doses of [19F]oritavancin (left) or desleucyl-[19F]oritavancin (right) after 1.6 ms of dipolar evolution. Full-echo spectra normalized to the control are shown at the bottom and REDOR differences are at the top of the figure. The REDOR difference measures the relative number of cross-links per peptidoglycan pentaglycyl bridging segment. At low concentrations, both drugs have a transpeptidase inhibitory effect. Chemical shifts are referenced to solid ammonium sulfate.