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. Author manuscript; available in PMC: 2018 Mar 14.
Published in final edited form as: Biochemistry. 2017 Mar 3;56(10):1529–1535. doi: 10.1021/acs.biochem.6b01125

Figure 5.

Figure 5

Transmission electron micrographs of S. aureus treated with vancomycin (left column), [19F]oritavancin (middle column), and desleucyl-[19F]oritavancin (right column). The top row shows a representative, large field of view. Vancomycin-treated S. aureus shows no significant change in cell shape, but general thinning of cell wall with diffused cell-wall staining for newly formed cell walls at the plane of cell division. Oritavancin- and desleucyl-[19F]oritavancin-treated S. aureus show thinning of cell wall at the septum of dividing cells and an aberrant cell shape.