Table 2.
Recombinant HDAC activity in response to bioactive compounds
| % HDAC activity | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| Bioactive Food Compound |
Class I HDACs |
Class IIa HDACs |
Class IIb HDACs |
|||||||
|
| ||||||||||
| 1 | 2 | 3 | 8 | 4 | 5 | 7 | 9 | 6 | 10 | |
| Apigenin | 76.4 | 90.4 | 72.7 | 76.5 | - | - | - | - | - | - |
| Baicalein | 64.7 | 48.6 | 59.2 | 58.7 | - | 76.6 | - | 66.1 | - | - |
| Baicalin | 89.0 | 72.9 | 81.7 | 78.3 | - | 81.8 | - | 91.5 | 86.2 | 84.7 |
| Berberine HCl | 50.5 | 70.3 | 48.3 | 46.8 | - | - | 60.9 | 45.0 | ||
| Caffeic acid | - | - | - | - | - | - | - | - | - | - |
| Dihydromyricetin | 90.0 | 73.9 | 82.5 | 81.9 | - | 73.4 | 94.0 | 92.5 | - | 86.3 |
| Emodin | 35.8 | 35.0 | 35.1 | 32.3 | 92.8 | 31.4 | 53.1 | 34.7 | 38.8 | 35.8 |
| EGCG | 89.0 | 72.9 | 81.7 | 89.1 | 82.5 | - | - | - | - | 91.2 |
| Gossypol | 42.6 | 15.1 | 42.1 | 40.7 | - | 51.5 | - | 44.5 | - | 42.6 |
| Hematoxylin | - | - | - | - | - | - | - | - | 81.8 | - |
| Indirubin | 61.5 | 58.7 | 56.6 | 58.4 | - | - | - | - | 65.7 | 67.0 |
| Kaempferol | 72.8 | 71.7 | 66.9 | 68.7 | - | 73.5 | - | 70.6 | - | 71.6 |
| Luteolin | 60.7 | 49.5 | 51.4 | 52.8 | - | 59.5 | - | 52.3 | - | 55.9 |
| Morin hydrate | 62.3 | 43.3 | 56.0 | 49.3 | - | 56.7 | - | 56.1 | - | - |
| Myricetin | 68.0 | - | 59.9 | 60.2 | - | 65.1 | - | 77.0 | - | 63.4 |
| Myricitrin | 75.1 | - | 67.7 | 65.4 | 93.5 | 68.3 | - | 69.3 | 87.2 | 67.0 |
| Palmatine | 44.8 | 17.5 | 47.1 | 40.9 | - | - | - | - | - | - |
| Quercetin dihydrate | 72.7 | - | 63.6 | 64.0 | 89.8 | 78.2 | - | 70.8 | - | 68.0 |
*
Recombinant proteins incubated with 50 µM bioactive compounds
No Inhibition (−)