. Author manuscript; available in PMC: 2017 Jul 13.

Published in final edited form as: Exp Dermatol. 2015 Jul 14;24(9):644–650. doi: 10.1111/exd.12773

Table 3.

A list of genes and their animal models suggested in sweat secretion

Genes	Genotype	Gross phenotype	Sweat gland phenotype	References
Foxa1	cKO (skin)	None	Anhidrosis	(94)
Best2	KI	None	Hypohidrosis	(94,112)
Itpr2 (InsP3R2)	KO	None	Hypohidrosis	(81)
Aqp5	KO	None	Hypohidrosis; Normal sweating	(32,33)
Chrm3	KO	Reduced body weight, dilated pupils	Not analysed	(75,113)
Slc12a2 (Nkcc1)	KO	Deafness, head-shaking, growth retardation, circling	Not analysed	(114–116)
Atp1a1 (Na⁺-K⁺ pump)	KO	KO perinatal lethal. Heterozygotes viable	Not analysed	(117)
Cftr	KO	KO poor growth, decreased survival, intestinal obstruction	Not analysed	(118–122)
Cftr	cKO	KO poor growth, decreased survival, intestinal obstruction	Not analysed	(118–122)
Scnn1a (ENaC)	KO	KO perinatal lethal	Not analysed	(123)
Scnn1a (ENaC)	cKO	KO perinatal lethal	Not analysed	(123)
Slc9a1 (Nhe1)	KO	2/3 of progeny die before weaning	Not analysed	(124)