Table 2.

Design strategy for different HOC organ compartment classes defined by metabolically supported functional scaling (MSFS) theory.

HOC organ compartment class	Tissue size	Blood volume
F-2D	Surface area constrained, ∝M1 scaling from macro human	Dimensions selected to maintain physiologic shear given fractional cardiac output
F-3D	Volume constrained, ∝M1 scaling from macro human	Calculated so that organ blood volume matches target fractional organ mass of whole body
F-2.5D	Divided into F-2D and F-3D domains with each domain scaled per F-2D or F-3D design rules