. Author manuscript; available in PMC: 2018 Mar 1.

Published in final edited form as: Technology (Singap World Sci). 2017 Mar 31;5(1):42–59. doi: 10.1142/S2339547817500029

Table 2.

Design strategy for different HOC organ compartment classes defined by metabolically supported functional scaling (MSFS) theory.

HOC organ compartment class	Tissue size	Blood volume
F-2D	Surface area constrained, ∝M¹ scaling from macro human	Dimensions selected to maintain physiologic shear given fractional cardiac output
F-3D	Volume constrained, ∝M¹ scaling from macro human	Calculated so that organ blood volume matches target fractional organ mass of whole body
F-2.5D	Divided into F-2D and F-3D domains with each domain scaled per F-2D or F-3D design rules