Table 3.
A comprehensive table of design parameters for a five-organ ×10−6 HOC. We propose increasing blood volume levels beyond those called for by conventional quarter-power scaling relationships (QPSRs) to account for engineering limitations in organ design. Chamber dimensions are selected to match in-vivo shear levels (F-2D) or match in-vivo mass (F-3D).
| Organ | Class | ×10−6 HOC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Surface area [mm2] | Tissue mass [mg] | Blood volume (BV) [μL] | % BV | % CO | Compartment dimension | |||||
| Length [mm] | Width [mm] | Height [mm] | ||||||||
| Lung | Endothelium | F-2D | 30 | 0.12 | 1.1 | — | — | — | — | — |
| Non-EC | F-2D | 40 | 0.16 | 1.4 | — | — | — | — | — | |
| Total | F-2D | 70 | 0.28 | 2.5 | 4 | 100 | 9.02 | 7.76 | 0.035 | |
| Liver | Endothelium | F-2D | 80 | 0.32 | 2 | — | — | 14.87 | 5.38 | 0.025 |
| Non-EC | F-3D | 34 | 1.75 | 1.03 | — | — | 1.57 | 1.57 | 1 | |
| Total | F-2/3D | 114 | 2.07 | 3.03 | 5 | 25 | — | — | — | |
| Heart | F-3D | — | 0.33 | 0.28 | 0.5 | 4 | 1.06 | 1.06 | 0.5 | |
| Fat | F-3D | — | 12.5 | 10.7 | 18 | 5 | 4.96 | 4.96 | 1 | |
| Blood | — | — | — | 60 | — | — | — | — | — | |
| “Other Tissues” | F-3D | — | 48.8 | 43.5 | 73 | 66 | 6.6 | 6.6 | 1 | |
| Blood Oxygen Content [BLO2; mM] | ~2 | |||||||||
| Cutaneous Respiration [mol/m/s/mmHg] | ≤3.8 × 10−11 | |||||||||
| Cardiac Output [mL/s] | 3.4 × 10−3 | |||||||||
| Intervessel Distance [IVD; μm] | 250 | |||||||||