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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Immunol. 2017 May 1;198(11):4448–4457. doi: 10.4049/jimmunol.1601089

Figure 7. MyD88 and PKD1 play a critical role in antibiotic-killed GBS-induced shock-mediated death of D-galactosamine (D-GalN)-sensitized mice.

Figure 7

(A) Wilde-type (n=5), MyD88−/− (n=4), or TLR9−/− (n=10) mice were challenged i.p. with antibiotic-killed GBS (2 × 108 cfu) plus D-GalN (30 mg). (B) C57BL/6 mice were injected i.p. with vehicle (n=9), Gö6976 (n=5), or Gö6983 (n=5) at 4 h and 1 h before and 2 h after the GBS challenge and then challenged i.p. with the antibiotic-killed GBS (2 × 108 cfu) plus D-GalN (30 mg). Fifteen mg of penicillin G was injected daily for the first 3 days to ensure complete killing of GBS. Viability of mice was observed up to 8 days. *, p < 0.05.